What is chemical genomics?
Chemical genomics is the study of protein function under the influence of ligands that bind to certain proteins or interfere with protein-protein interaction. [1] In other words, chemical genomics identifies a relationship between a variety of compounds (which can include drugs, chemicals, or other biological compounds such as proteins and lipids) and the resulting effect on protein function. Figure 1 (below) shows the process by which chemical genomics operates. Identifying these relationships can be useful in identifying the change in protein function caused by a mutation or identifying potential treatments for a condition.
Results and Discussion
Using PubChem, I searched for significant small molecules or phenotypes and found that ARNT shows significant interaction with Hydrocortisone. [2] Hydrocortisone is found in large amounts in breast milk, is used in many common creams and medications, and is found to generally inhibit inflammatory transcription factors. [3]
References:
[1] Kubinyi, H. (2007, April 11). Chemogenomics. Retrieved from https://www.sciencedirect.com/science/article/pii/B008045044X001139
[2] https://pubchem.ncbi.nlm.nih.gov/gene/405#section=Drug-Gene-Interactions&fullscreen=true
[3] Hydrocortisone. (n.d.). Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/5754#section=Drug-Effects-during-Lactation
Header image: https://www.drugtargetreview.com/news/48519/ai-predict-outcomes-complex-chemical-reactions/
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[2] https://pubchem.ncbi.nlm.nih.gov/gene/405#section=Drug-Gene-Interactions&fullscreen=true
[3] Hydrocortisone. (n.d.). Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/5754#section=Drug-Effects-during-Lactation
Header image: https://www.drugtargetreview.com/news/48519/ai-predict-outcomes-complex-chemical-reactions/
All other images are linked