What is Gene Ontology (GO)?
The Gene Ontology (GO) of a gene holds valuable information about the function of a gene and its proteins at the biological, molecular and cellular levels. [1] This information will give us better insight on the function of ARNT and how it may contribute to CAD.
Gene Ontology of ARNT
Cellular ComponentThe Human Protein Atlas shows that ARNT expression is found primarily in the neucleus of the cell.
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Biological ProcessOn the biological level, ARNT is found to work as a transcription factor.
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Molecular FunctionARNT is comprised of domains that allow it to bind within itself and to other proteins.
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Discussion
By identifying these functions of ARNT on the biological, molecular and cellular levels it allows us to better understand how the ARNT gene is potentially associated with CAD. Since the GO indicates that it functions as a transcription factor in the nucleus it is possible that it works to up regulate genes that are involved in the formation of plaque in the coronary artery.
References
[1] About the GO. (n.d.). Retrieved from http://geneontology.org/docs/introduction-to-go-resource/
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